The Colorado Buffaloes and Houston Cougars square off in a high-stakes Week 3 Big 12 clash on Friday, September 12, 2025, at TDECU Stadium in Houston, Texas. Kickoff is set for 7:30 p.m. ET and will air nationally on ESPN.
Oddsmakers have installed Houston as a 4.5-point favorite, with the over/under set at 45.5 points. The Cougars enter the game at 2-0, showing consistency on both sides of the ball. Quarterback Conner Weigman has impressed with his dual-threat playmaking, while running back Dean Connors continues to fuel Houston’s ground game.
Colorado (1-1) bounced back last week with a 31-7 victory over Delaware. The Buffaloes are expected to start Ryan Staub at quarterback, who provided a spark off the bench. However, injuries in the secondary and inconsistency on offense remain concerns heading into a tough road test.
Experts lean toward Houston covering the spread, pointing to the Cougars’ defensive edge and home-field advantage. Prop bets drawing interest include Connors surpassing 52.5 rushing yards and Staub throwing for over 1.5 touchdowns.
Prediction: Houston wins a close contest, covering the spread with a defensive-driven game. Expect the under 45.5 total points to cash.
